The chronic plantar ulcer is one of the commonest complications leading to functional disability and disfigurement in leprosy. Secondary bacterial infections on chronic ulcers hinder wound healing. Understanding of biology of infected plantar ulcers remained one of the most neglected areas both in terms of research and intervention. Since the microbial ecology and the chemotherapeutic susceptibilities of the microbes are poorly understood the clinicians are forced to prescribe antimicrobial agents empirically for treating infected ulcers. Clinical correlation of pathogenic and commensal organisms on chronic foot ulcers would help in formulating appropriate intervention strategies for tackling the infections and preventing AMR.Preliminary findings from the study indicate the profile of pathogenic bacteria (S.aures, P. auruginosa, Proteus spp, and others). We reported first time, biofilm-producing bacterial infections in chronic ulcers in leprosy which delays the wound healing. The study also demonstrated the in vitro antimicrobial and antibiofilm activity of bacteriocin on S. aureus (on clinical isolates identified from leprosy foot ulcers). Further evaluation of bacterial on animal models was carried out at the Norwegian site. We need to make the bacteriocin formulation in the form of gel/spray/patches/ or any possible forms on foot ulcers in leprosy patients to treat bacterial infections (topical bacteriocins, in lieu of the human Randomised Controlled Trail).

• Preliminary findings from the study indicate the profile of pathogenic bacteria (S.aures, P. auruginosa, Proteus spp, and others).
• We reported first time, biofilm producing bacterial infections in chronic ulcers in leprosy which delays wound healing. 
• The potential bacteriocin was identified against S. aureus.
• Demonstrated the in vitro antimicrobial and antibiofilm activity of bacteriocin on S. aureus (on clinical isolates identified from leprosy foot ulcers).